| Ongoing MCTG Funded Research Studies |
|
Title |
Principal Investigator |
Type of Study |
Projected Enrollment |
Funding |
Status |
| High-volume Hemofiltration for critically ill burn patients with septic shock and mild acute kidney injury |
Kevin Chung, MD
Ft. Sam Houston, TX |
Non-blinded randomized controlled trial comparing intervention with early high-volume hemofiltration (HVHF) plus 'contemporary' care alone in critically ill adult burn patients who develop septic shock with mild acute kidney injury |
120 patients in 10 centers |
Yes
Dept of Defense Combat Casualties Grant |
Pre-enrollment, accepting additional sites |
| Development of an inhalation injury scoring system |
Kevin Foster, MD
Phoenix, AZ |
Non-interventional, multi-center, 2-phase prospective trial to construct and validate an accurate and predictive scoring system for burn subjects with inhalation injury |
1,000 patients 15-20 centers |
Yes
Dept of Defense Combat Casualties Grant |
Pre-enrollment, not accepting additional sites |
| Effects of enteral glutamine supplementation on mortality and infectious morbidity in severly burned patients |
Paul Wischmeyer, MD
Univ. Colorado |
Prospective, double-blinded randomized clinical trial of the effect of glutamine supplementation of enteral nutrition on infectious morbidity/mortality in burn patients |
1014 pts with burns ≥ 20% TBSA |
Yes
Dept of Defense Combat Casualties Grant |
Pre-enrollment, not accepting additional sites |
| PCR-based detection of Staph aureus in burn patients |
Nam Tran, PhD
Sacramento, CA |
PRCT using the only FDA-approved near-patient nucleic acid recognition (NAR) device for the detection of methicillin sensitive Staphylococcus aureus (MSSA), and methicillin resistant Staphylococcus aureus (MRSA). |
240 patients in 4 centers |
Yes
Dept of Defense Combat Casualties Grant |
Pre-enrollment, not accepting additional sites |
| Community-based exercise program in adults with severe burns |
Oscar Suman, PhD
Galveston, TX |
Prospective, randomized, controlled evaluation of a structured exercise program on burn rehabilitation |
60 pts over 2 years |
Yes
Dept of Defense Combat Casualties Grant |
Pre-enrollment, not accepting additional sites |
Prospective, Randomized Trial of Restrictive Versus Liberal Blood Transfusion Policy in Burns Greater than 20% TBSA |
Tina Palmieri, MD
U California, Davis
|
Prospective, randomized, clinical trial of restrictive (Hgb 7-8 gr/dL) is associated with equivalent survival as a liberal (Hgb 9-10 gr/dL) transfusion in patients with burns ≥ 20% TBSA |
400 pts ≥ 20% TBSA, 13 centers |
YES USAMRMC
MCTG-sponsored |
Center enrollment currently closed, patient enrollment begins summer, 2009 |
Burn Patient acuity Demographics, Scar contractures and Rehabilitation Treatment Time Related to Patient Outcomes |
Reginald Richard, RPT USAISR
|
Prospective creation of descriptive patient database focusing on patient demographics, rehabilitation treatments, scar contractures, and total rehabilitation treatment time. |
800 patients
19 burn centers |
YES TATRC
MCTG-sponsored |
Center enrollment closed, anticipate patient enrollment summer/fall 2009 |
| Ongoing MCTG Member Initiated Research Studies |
|
Title |
Principal Investigator |
Type of Study |
Projected Enrollment |
Funding |
Status |
Percutaneous Peritoneal Decompression and Abdominal Compartment Syndrome: A Prospective, Randomized, Multi-Institutional Study |
Barbara Latenser, MD
University of Iowa |
Prospective, randomized, unblinded study of 240 patients nationwide. Half will receive percutaneous peritoneal decompression, controls will receive standard monitoring/ care. |
240 patients
15 centers |
Catheters provided by Cook Critical Care. PI will analyze data |
Enrollment is ongoing. Five centers enrolled to date |
A Comparative Study of the Recell™ Device and Autologous Split Thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries |
James Holmes, MD
Wake Forest University Burn Center |
Prospective, randomized clinical trial of the ReCell™ epidermal suspension technique compared to conventional STSG for patients with burns ≤ 20% TBSA |
100 pts ≤ 20% TBSA, 10 centers |
YES AFIRM/DOD |
Center enrollment closed with enrollment start date by 7/1/09 |
International Classification of the External Causes of Injury: ICECI |
Michael Peck, MD
Arizona Burn Center |
Prospective observational process evaluation of implementing software containing ICECI into existing NTRACS burn registries |
10 centers (9 so far) |
IAFF |
Presented at 9th World Conference, Injury prevention and safety, 2008
Abstract to be presented at 2009 ABA meeting. |
|
Title |
Principal Investigator |
Description |
Outcome |
| Across State Lines: Healthcare Accessibility, Fiscal and Legislative Concerns Facing the ABA |
Michael Peck, MD
Arizona Burn Center |
Retrospective review of patients admitted to US burn centers comparing resource utilization for in-state vs. out-of-state patients |
Manuscript submitted for publication |
Burn Mortality in Patients Age 75 Or Greater |
Daniel Caruso, MD
Karen Richey, RN Arizona Burn Center |
Review of mortality among elderly patients |
Abstract presented at 2006 ABA meeting |
A Retrospective Review of DRG 504 |
Richard Kagan, MD University of Cincinnati |
Review of 107 patients with DRG 504 who required mechanical ventilation from 3 institutions documenting inadequate reimbursement for care. |
Published J Burn Care Res 2007;28:664-8 |
Blood Transfusion in Burns: What Do We Do? |
Tina Palmieri, MD
University of California Davis |
Survey among 55 burn center directors documenting that "restrictive" transfusion policies are not widely followed. |
Published J Burn Care Res 2004;25:71-5 |
Effect of Blood Transfusion on Outcome after Major Burn Injury: A Multicenter Study |
Tina Palmieri, MD
University of California Davis |
Review of 666 patients from 21 burn centers documenting a relationship between number of transfusions and mortality. |
Published Crit Care Med 2006;34:1602-7 |
| Effects of Oxandrolone on Outcome Measures in the Severely Burned: A Multicenter Prospective Randomized Double-Blind Trial. |
Steven Wolf, MD
US Army Institute of Surgical Research |
Prospective randomized trial of oxandrolone supplementation in 81 patients treated at US burn centers.
Oxandrolone patients had shorted LOS. |
Published J Burn Care Res 2006;27:131-9 |
| Current Management of Purpura Fulminans: A Multicenter Study |
Petra Warner, MD University of Cincinnati |
10-year review of 70 patients with purpura fulminans treated at 7 burn centers. Skin grafting or amputation required in 90% of patients. |
Published J Burn Care Rehabil 2003;24:119-26 |
| A Multicenter Review of Toxic Epidermal Necrolysis Treated in U.S. Burn Centers at the End of the Twentieth Century |
Tina Palmieri, MD University of California Davis |
Review of 199 patients with SJS/TENS treated at 15 burn centers from 1995-2000. Mortality of 32%. |
Published J Burn Care Rehabil 2002;23:87-96 |
| Burn Depth Assessment Questionnaire |
Joel Fish, MD
Ross Tilley Burn Center |
|
Abstract presented ISBI, Montreal, 2008. Manuscript submitted for publication. |
| The Continued "Dangerous"(?) Use of Albumin in the Management of Acute Burn Injury: A Survey of the ABA Multicenter Trials Group. |
Bruce Cairns, MD
NC Jaycee Burn Center |
|
Abstract presented at 2004 ABA meeting |
| DRG 272: Does It Provide Adequate Burn Center Reimbursement for the Care of Patients with Toxic Epidermal Necrolysis? |
Richard Kagan, MD University of Cincinnati |
Multicenter review of 33 patients with SJS/TENS from 6 burn centers documenting inadequate reimbursement. |
Abstract presented at 2004 ABA Annual Meeting
Published J Burn Care Res 2007;28:669-74 |
| A Multicenter Review of Fungal Infections In Burn Patients |
James Ballard, MD University of Utah |
Review of 435 patients with positive fungal cultures from 15 US burn centers. Systemic treatment, number of sites, and cultures positive for aspergillus or mold associated with increased mortality. |
Abstracts presented at 2006 and 2007 ABA Annual Meetings.
Published J Burn Care Res 2008;29:213-21 |
Regional Burn Center Utilization: Is the Patient Composition of Regional Burn Centers Changing? |
Amalia Cochran, MD University of Utah |
Retrospective review of admissions from Utah, Washington, Minnesota, Iowa, Loyola
|
Abstract presented at 2009 ABA Annual Meeting.
Published J Burn Care Res 2010 Jan-Feb;31(1):130-6 |
